Hypercoagulability

Hypercoagulability is common, especially in patients with hypercortisolism: cortisol blocks production of adenosine-derivatives. IMG

ADP receptor P2Y12 on platelets is targeted by many of the anticoagulation drugs including ticlopidine and clopidogrel PMID 22183178: adenosine-similar structure is readily apparent in ticagrelor. Detailed 3D modeling of binding sites for ATP/ADP of P2Y12 here PMID 17110146. IMG

Warfarin is a xanthine-similar anticoagulant: xanthines are known to block adenosine receptors: e.g. caffeine. 

Rivaroxaban has a xanthosine (Xo)-similar structure: given caffeine as an adenosine receptor blocker, a xanthosine-similar adenosine receptor blockade would not be surprising. IMG

Hydroxyurea may act by reducing RNR activity PMID 34777360 (converting ATP to dATP, etc) in order to increase ATP, decrease hypercoagulability in sickle cell patients?