Clinical Guide

Although the theory is complex and based in hundreds of citations from the medical literature, the practical question is how to treat a patient's symptoms. This document links symptoms in traditional ROS format to hypothetical purine imbalances (search the site for basic literature review) and medications that may tend to alleviate (or exacerbate) those imbalances. 

Each capital letter represents a purine, while lines/arrows represent purine metabolism enzymes that seem to be activated or inhibited by various listed medications, based on a combination of chemical structure and clinical experience. The details of which purine and which enzyme are understated in this chart to provide maximum attention to treatment.

These charts have helped me to more accurately predict response to complicated combinations of medicines and symptoms. I have been able to watch in detail as symptoms are transformed, then resolved.

My hope is that providers can join me in using this theory as an additional way to formulate symptoms and treatment. Agents noted as unnecessarily opposing each other may be able to be streamlined. Specific agents within current accepted clinical practice may be prioritized in order to more precisely target and treat symptoms. Where traditional recommendations have been exhausted, similarities in chemical structure or apparent effect may point to off-label options.

I recommend writing hypothesized deficit/excesses from pg1 onto the letters on pg 2, then highlighting the current medications, then considering medication changes.